HPR

HPR may refer to:
 * Handley Page (Reading)
 * Haptoglobin-related protein, a protein and gene in humans
 * Harvard Political Review
 * Hawaii Public Radio
 * Heading, pitch, roll; see flight dynamics
 * Heartland Public Radio
 * Heparanase
 * High-power rocketry
 * Highly Protected Risk (insurance terminology); see FM Global
 * Holding period return
 * IBM Home Page Reader, a self-voicing web browser for blind users
 * Homiletic and Pastoral Review
 * Hornsdale Power Reserve, a utility-scale battery in South Australia
 * Host plant resistance
 * Human Proteome Resource program
 * Hungarian People's Republic
 * Hunt, point, and retrieve, categories of dog breeds; see pointing breed
 * Hydroacoustic Position Reference
 * Honza PRůša (painter, writer and actor from Czech Republic)