Big Run

Big Run may refer to:


 * Big Run, Ohio
 * Big Run, Jefferson County, Pennsylvania
 * Big Run, Marion County, West Virginia
 * Big Run, Marshall County, West Virginia
 * Big Run, Webster County, West Virginia
 * Big Run, Wetzel County, West Virginia
 * Big Run (East Branch Fishing Creek), in Sullivan County, Pennsylvania
 * Big Run (Little Muncy Creek), in Lycoming County, Pennsylvania
 * Big Run (South Branch Potomac River), in Hampshire County, West Virginia
 * Big Run (West Branch Fishing Creek), in Sullivan County, Pennsylvania
 * Big Run (Slippery Rock Creek tributary), in Butler County, Pennsylvania
 * Big Run, a 1989 arcade game developed by Jaleco