New Madrid

New Madrid may refer to:


 * New Madrid County, Missouri, a county in the U.S. state of Missouri
 * New Madrid, Missouri, a city in New Madrid County
 * New Madrid Seismic Zone, a major seismic zone in Missouri, Tennessee, and Arkansas
 * New Madrid earthquake, a series of four earthquakes that occurred in late 1811 and early 1812
 * "New Madrid" (song), by Uncle Tupelo from their 1993 album Anodyne
 * New Madrid, a literary journal published by Murray State University