20th Century Blues

20th Century Blues may refer to:


 * Blues, the musical form and genre
 * "Twentieth Century Blues", a song from the 1931 musical Cavalcade by Noël Coward
 * 20th Century Blues (Marianne Faithfull album), 1996
 * 20th Century Blues (Robin Trower album), 1994
 * 20th Century Blues, (play by Susan Miller), 2018