Tinospora cordifolia

Tinospora cordifolia, which is known by the common names gurjo, heart-leaved moonseed, guduchi, and giloy,, is an herbaceous vine of the family Menispermaceae indigenous to tropical regions of the Indian subcontinent. Despite centuries of use in traditional medicine to treat various disorders, there is no high-quality clinical evidence that it has any effect on diseases.

Botanical description
It is a large, deciduous, extensively-spreading, climbing shrub with several elongated twining branches. Leaves are simple, alternate, and exstipulate with long petioles up to 15 cm long which are roundish and pulvinate, both at the base and apex with the basal one longer and twisted partially and half way around. It gets its name heart-leaved moonseed by its heart-shaped leaves and its reddish fruit. Lamina are broadly ovate or ovate cordate, 10–20 cm long or 8-15 cmbroad, seven nerved and deeply cordate at base, membranous, pubescent above, whitish tomentose with a prominent reticulum beneath. Flowers are unisexual, small on separate plants and appearing when the plant is leafless, greenish-yellow on axillary and terminal racemes. Male flowers are clustered, but female flowers are usually solitary. It has six sepals in two series of three each. The outer ones are smaller than the inner. It has six petals which are smaller than sepals, obovate, and membranous. Fruits aggregate in clusters of one to three. They are ovoid smooth drupelets on thick stalks with sub terminal style scars, scarlet or orange colored.

Ecology
Endophytic fungi colonize the living, internal tissues of their host without causing any harmful effects. A recent study has shown that 29 endophytes belonging to different taxa were present in the samples collected from T. cordifolia.

Extracts of the endophytic fungus Nigrospora sphaerica obtained from T. cordifolia were found to have insecticidal properties against the Oriental leafworm moth (Spodoptera litura), a polyphagous pest.

Phytochemicals
Tinospora contains diverse phytochemicals, including alkaloids, phytosterols, glycosides, and mixed other chemical compounds. Columbin, tinosporaside, jatrorhizine, palmatine, berberine, tembeterine, tinocordifolioside, phenylpropene disaccharides, choline, tinosporic acid, tinosporal, tinosporon, and tinosporide have been isolated from Tinospora cordifolia.

Traditional medicine
In Ayurveda, Tinospora has been used over centuries to treat various diseases. Due to inadequate design or other weaknesses of clinical research on Tinospora, there is no high-quality scientific evidence that it has any anti-disease effect, and is not used as a prescription drug. Indian ministry of Health and Family Welfare recommends consumption of Guduchi (Giloy) Ghana Vati for management of mild COVID19. []