SPB

SPB may refer to:

Places

 * Scappoose Industrial Airpark, Oregon, USA, FAA LID
 * Schynige Platte Bahn, a mountain railway in Switzerland
 * Charlotte Amalie Harbor Seaplane Base, U.S. Virgin Islands, IATA airport code
 * Saint Petersburg, Russia

Science and technology

 * Shortest Path Bridging in the IEEE 802.1aq standard
 * Slowly pulsating B star, a type of variable star
 * Spindle pole body, the functional equivalent of the mammalian centriole in yeast
 * Superpressure balloon

Other uses

 * Society of the Precious Blood, Anglican religious order
 * S. P. Balasubrahmanyam (1946-2020), Indian playback singer, actor, music director, voice actor and film producer
 * SPB Software, mobile software developer
 * Belarus Free Trade Union, a trade union in Belarus
 * Sparisjóðabanki, also known as SPB hf., a defunct bank in Iceland